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The bioactive peptides ability to inhibit ACE is enhanced by the presence of an aromatic amino acid at its carboxyl terminus
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Kim R, Hashimoto A, Markosyan N, Tyurin VA, Tyurina YY, Kar G, Fu S, Sehgal M, Garcia-Gerique L, Kossenkov A, et al

Other factors presumed to play a role in IR are tumor necrosis factor , adiponectin, leptin, interlukin-6 and other adipokines