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In triple-negative breast cancer (TNBC), cells with high SLC7A11 expression consume more Gln and are more sensitive to Gln starvation compared to other breast cancer cells

Furthermore, higher levels of IGF-1 are associated with higher bone mineral density in adult obese individuals (230)

Semaglutide has become very popular because clinical studies show it can lead to about 15% body weight loss on average

Notably, alternative strategies have also been explored, such as LPS/IL-22 co-stimulation to model hyperproliferation [41], LPS/TNF- for inflammatory responses [42], TNF-/IL-17 A combination [43] IL-22/TNF- co-treatment [44], or IMQ application [45]