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Knocked down PINK1 in SHSY5Y cells results in inhibition of mDNA synthesis, disruption of key indicators of mitochondrial activity, mitochondrial membrane potential, and suppressed production of ATP (Gegg et al

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A subsequent study of advanced solid malignant tumors by the Fert laboratory developed a radiomic signature for CD8 + T cells to estimate CD8 + T-cell counts in the TME and concluded that in patients treated with anti-PD-1 therapy and anti-PD-L1 therapy, a high baseline radiomic score was associated with a high objective response rate (ORR) at 3 months [162]