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Pre-existing risk factors common in the diabetes population further compound concern: Older age (reduced intrinsic factor production) Autoimmune conditions (pernicious anaemia, thyroid disease) Previous gastric surgery or gastrointestinal disorders Vegetarian or vegan dietary patterns There is no established link between semaglutide pharmacology and B12 metabolism in the MHRA-approved product information, but the clinical context in which Ozempic is prescribed creates a population where B12 awareness is prudent

doi: 10.1016/j.neuro.2010.05.008 36 MolesLEgimendiaAOsorio-QuerejetaIIparraguirreLAlberroASurezJet al

Not for human use, medical use, diagnostic use, or veterinary use

Plan of analysis All analyses will initially be done on an intent-to-treat basis