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Thus, POR-dependent cholesterol synthesis is essential during limb and bone development

116 Similarly, in pancreatic ductal adenocarcinoma, abnormal ClpP activation can inhibit tumor progression by disrupting mitochondrial protein homeostasis

Kronstein-Wiedemann R, Stadtmller M, Traikov S, Georgi M, Teichert M, Yosef H, et al

Melanin acts as a natural barrier against UV radiation, and its reduction can lead to a higher risk of sunburn, premature ageing, and skin cancer