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Schmidt and Dringen 2009, 2010), (3) accelerated export of GSH due to activation of the transporters mediating GSH export (Arend et al

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-kappaB pathways in diabetic neuropathy

thanks the support from the Israel Science Foundation (1388/22)

Auspiciously, we found that PKM2 mediates DRD2-induced GSH production and is selectively expressed in astrocytes, indicating that PKM2 dimerization is an ideal approach to restore GSH synthesis and prevent side effects induced by effects on neuron functions