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Description
Glutathionylated roGFP2 C151S , roGFP2 C208S , PfGrx C88S , and PfGrx C32S/C88S were produced by incubation of the reduced enzymes with 5 mM GSSG for 60 min on ice
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The primary endpoint was area under the cagrilintide plasma concentration curve from time zero extrapolated to infinity (AUC 0 ) from baseline (day 1) to day 36 (end of study)
Researchers emphasized that this non-invasive route could serve as a model for other neuroactive synthetic peptides, providing a foundation for future translational studies on neurodegenerative conditions
