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Description
Importantly, although pre-existing humoral and cellular immunity to commonly used Cas orthologs (e.g., SpCas9/SaCas9) has been documented in human populations (295), published clinical experience with CRISPRCas9 therapies to date has not reported clinically meaningful Cas9-directed immune toxicities (296)
Cardiolipin, mitochondria, and neurological disease
Yasui-Furukori N et al
Cell Signal (2010) 22(2):24756
