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Furthermore, W32 can be oxidized by the carbonate radical produced by SOD1 bicarbonate-dependent peroxidase activity, leading to the formation of a SOD1 covalent dimer cross-linked by a di-tryptophan bond

JAMA 326 , 926939 (2021)

It may be reversible in its early presentation, but can also result in long term institutional care and eventual death

The selection process was continued for 72 h to ensure the expansion of a population of stably transduced cells