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We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable. Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism

Diabetes 61 , 30783080 (2012)

High-dose protocols (e.g., 50,000 IU administered weekly or every two weeks) and lower daily doses (e.g., 2000 IU/day) have been evaluated, with generally favorable but not uniformly consistent effects on pain and biochemical markers

Several studies have previously reported the inhibitory effect of selenium on kidney stones