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Description
Surgical procedures: Gastric bypass surgery or removal of parts of the small intestine can impair B12 absorption
Metabolic effects, including weight change, insulin resistance, and altered appetite, further affect sex hormones and ovulatory regularity
Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations
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