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BakkerPButterLKorsLTeskeGAtenJSutterwalaFet alNlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation
Thioether bridges, formed via alkylation or native chemical ligation, introduce a non-reducible C-S bond that generally preserves native peptide topology (Zhao et al., 2020
Cells 10 , (2021)
Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response
