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Description
(2004) measured formate in urine and used it as a mode-of-action marker
2.2.1 Oxidative stress and mitochondrial dysfunction METH significantly increases the production of ROS and reactive nitrogen species, overwhelming antioxidant defenses in neurons
98% positive feedback
GSH is negatively charged at physiological pH so it is unable to cross both the outer mitochondrial membrane (OMM) and the inner mitochondrial membrane (IMM)
