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Morphologically, light and electron microscopic examinations of irradiated testes have revealed marked disorganization, desquamation, and vacuolization of the germ cells of rats seminiferous tubules, as well as formation of multinucleated giant cells in the germinal epithelium following spermatogenesis arrest, compared to the unirradiated testes

These studies suggest that inhibition of the L-carnitine shuttle by pharmacological inhibition of CPT I, as in the case of etomoxir, results in liver steatosis

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[DOI] [PMC free article] [PubMed] [Google Scholar] Schmidli R, 2016
