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These combinations lead to the loss of -ketoglutarate (-KG) production and simultaneous gain of 2-HG that alters transcriptional patterns of histone methylation regulation and whole DNA methylation in favor of tumor growth ( Pyruvate kinase M (PKM) is the glycolytic enzyme that converts phosphoenolpyruvate to pyruvate

ATP also plays an important role in signal transduction in cells in which it is utilized by enzymes such as kinases to modify both protein and non-protein substrates in response to specific stimuli 26,27

Nevertheless, tN-endogenous glia interactions, and in particular oligodendroglia, remain largely understudied and constitute a crucial hurdle to graft integration