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As research continues, we may find that this gut-derived hormone holds the key to not only reversing metabolic disease but also enhancing longevity and vitality

Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, Petrovic A, Kokot A, Gojkovic S, Krezic I, Drmic D, Rucman R, Seiwerth S

Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig

In vitro studies have characterised its binding interactions with nitric oxide-related signalling systems and effects on extracellular matrix protein expression in cell culture models
