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This inhibitor led to accumulation of DOPAL and to selective damage of dopaminergic neurons in primary cell cultures and in a zebrafish model system (85)
However, in a subsequent 24-week trial involving 536 obese participants, AOD 9604 did not achieve statistically robust, clinically meaningful weight-loss outcomes versus placebo, and the obesity-drug development program was discontinued around 2007
Nakamura T, Harada K, Kamiya T, Takizawa M, Kppers J, Nakajima K, et al
