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ZonoozSRHasaniMMorvaridzadehMPizarroABHeydariHYosaeeSet al

PLoS ONE 6 , e20638 (2011)
Regulatory Approval : Ensure that the product is compliant with necessary medical regulations and standards

The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)