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They also showed that while p53 abnormalities had only affected one allele in typical CLL, 4 out of 7 CLL/PLL cases had both alleles inactivated, implying a correlation between the accumulation of p53 abnormalities and CLL/PLL developments [458]

This competitive binding may offer advantages over covalent inhibition by enhancing specificity and reducing the risk of non-specific interactions, which can limit covalent inhibitors therapeutic use

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The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection