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[PubMed] [Google Scholar] 26.Morazzoni P, Montalbetti A, Malandrino S, Pifferi G

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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

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