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Human gut microbiota/microbiome in health and diseases: a review

Short-term IP dosing elicited stronger transcriptional activation in females despite behavioral improvement being restricted to males, whereas longer-term IN treatment improved performance in both sexes despite divergent molecular responses
Therapeutically, these insights underscore the need for microbiome-responsive strategies
55 Besides, adropin could promote eNOS activation and perfusion recovery after hindlimb ischemia by upregulating VEGFR2, 56 suppress proliferation and phenotypic modulation of VSMCs induced by angiotensin II via AMPK/ACC signaling, 46 and attenuate vascular calcification by repressing VSMCs osteogenic differentiation through JAK2/STAT3 signaling, 57 as well as inhibit TNF--induced THP1 monocyte adhesion to VECs, prevent macrophages from polarizing into a pro-inflammatory phenotype and reduce the formation of atherosclerotic lesions in apoE / mice