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Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]

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Development and application of a comprehensive lipidomic analysis to investigate tripterygium wilfordii-induced liver injury

Because all of these factors are made in the liver and several are vitamin K dependent, a prolonged PT often indicates the presence of significant liver disease