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OCTN: A small transporter subfamily with great relevance to human pathophysiology, drug discovery, and diagnostics

An excessive production of caffeine-dependent gastric hydrochloric acid can affect the degree of absorption of concomitantly used drugs by degrading the drug, converting the drug substance into an insoluble form, and altering its dissolution rate

Mol Psychiatry 28:284297 Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism