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Metabolism 49:38 Bjarnason I, Hayllar J (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans

While variance in plasma levels were noted, contrasting results have been seen when looking at in vivo studies

In vivo experiments in rats demonstrate that administration of Gln before ischemia/reperfusion injury or surgical manipulation can enhance GSH concentrations and provide protection against oxidative stress in various tissues (e.g., cardiac, intestinal, and lung) [25, 26]

Efficacy and absorption issues: Glutathione supplements have limited ability to pass through the digestive tract and be effectively absorbed