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Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis

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Although the relationship between fat and testosterone levels may be compounded by comorbidities, some research suggests that one of the underlying mechanisms governing this is the coordinated action of E2 activation of estrogen receptor alpha (ER) through increased production of E2 at the level of adipose tissue via testosterone aromatization [148]

Interestingly, a study found that mutations in CHCHD2 in fibroblasts from PD patients lead to fragmentation and reduced OXPHOS activity of complexes I and IV [104]