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Soldatos CR, Dikeos DG, Paparrigopoulos TJ
Figure 3

A 2025 systematic review and meta-analysis in Frontiers in Pharmacology (Mazur and colleagues, 16 studies, 6,098 participants) found that oral, sublingual, and intramuscular B12 all raised serum cobalamin to a comparable degree, with no statistically significant difference between routes

B12 Intramuscular Dose Recommendations The usual dose for vitamin B12 injections is 1000 mcg (1 mg)
