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Regulation of FOXO ubiquitination by Mdm2 is likely to be direct since Mdm2 and FOXO co-immunoprecipitate

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It is important to note, however, that patients in the duloxetine group reported more moderate-intensity adverse effects (fatigue, somnolence, insomnia) compared to those in the placebo group, which resulted in a higher dropout rate (11% vs
Lachapelle et al., 2013)
