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We found that PARK2+R mice had decreased latency to fall off (82.91 5.97 SEM) and decreased rounds per minute (22.17 1.54 SEM) on the rotarod tests compared to none-exposed mice (118 11.38 SEM, p = 0.007 and 31 2.5 SEM, p = 0.004, respectively) (Fig

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Second, full activation of mTORC1 requires mTORC1 sensing of the BCAAs via many mediators, the best understood of which is the sestrins/gator/RAG/ragulator pathway (Chantranupong et al., 2014)