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Under this snowball interaction, coupled with the unique central nervous system microenvironment, such as the blood-brain barrier (18) and hypoxia (19, 20), acidic tumor microenvironment (2, 21), tumor cells can escape immune surveillance (22) and eventually set the glioma immunosuppressive microenvironment (23, 24)

The study further identified many antimalarial drugs which have shown antimalarial activities against a strain moderately resistant to chloroquine [87]