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The two major pathways for the degradation of proteins involve the selective elimination through the ubiquitin-proteasome system (UPS) and removal through chaperone-mediated autophagy (CMA) (128)

doi: 10.3390/ijms24055053 8 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

After the addition of TGF1 to the low-glucose medium, -SMA expression in PSCs increased significantly
The safety record is generally placebo-like, but several specific findings deserve attention
