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Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and receptor-independent manners

M., Murray, L., Niu, X

Emerging studies indicate alternative pathways that utilize various signaling molecules and metabolic processes to modulate ferroptosis independently of GPX4 and System Xc-

The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP