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HUVECs grown on a stiffer gel of 10 kPa showed more VEGFR-2 endocytosis, a measure of activation, compared to HUVECs grown on a more compliant matrix of 1 kPa ( Hippo Pathway The Hippo pathway involves a kinase cascade leading to downstream transcription factors YAP and TAZ, which are involved in organ development as well as cell contractility, migration, and proliferation (225)

Here we report the crystal structure of the mouse -OR, bound to the subtype-selective antagonist naltrindole