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Furthermore, mitochondrial dynamics contribute to pathological changes in AD, modulating several signaling pathways, including those involving Ca 2+ , AMPK, and nitric oxide [267]

Caspase inhibitors, overexpression of the anti-apoptotic Bcl-2, p53 inhibitors, and the STAT1 inhibitor epigallocatechin gallate, which can reverse Bcl-2 family equilibrium toward antiapoptosis, have been proposed as protective measures for hair cells against apoptosis caused by cisplatin (Wu et al

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This increase in GH enhances hepatic production of insulin-like growth factor-1 (IGF-1), a key mediator of anabolic and metabolic effects