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Genome-wide analyses have identified CpG sites significantly associated with both systolic and diastolic blood pressure, with some methylation changes shown to both predict and be influenced by blood pressure over time [67]
While PLC1 is ubiquitously expressed in multiple tissues, PLC2 is mainly expressed in hematopoietic cell lineages 34
In addition, GRK6 regulates insulin homeostasis, an abnormality which participates in the pathogenesis of hypertension [137]
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