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The uptake and metabolism of polyunsaturated fatty acids (PUFAs), and the synthesis of PUFA phospholipids (PUFA-PLs), crucially shape cellular sensitivity to ferroptosis

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Future studies should therefore assess intestinal permeability and the translocation of microbial products (e.g., endotoxins) into the portal circulation in WD patients, and examine their correlation with hepatic copper levels and disease severity

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