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Supplementary Materials Data Availability Statement Data will be made available on request.

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In vitro studies have demonstrated that RCC cells exhibit high expression of both IGF-1 and IGFBP-3, which have opposing effects: inhibition of IGF-1 reduces RCC cell proliferation, while blocking IGFBP-3 increases it.39 This response occurs because IGF-1 signals through IGF1R triggering proliferative effects and promoting IGFBP-3 expression, the latter modulating the IGF-1 actions