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Adequate intake of this mineral is needed for maternal thyroid hormone production, and thyroid hormone is needed for myelination of the central nervous system and is thus essential for normal fetal brain development (147)

Mechanistically, chronic hyperinsulinemia resulting from decreased responsiveness to insulin promotes excessive synthesis and release of leptin from adipose tissue (154)

However, the effect of IGF/IGF-1R signaling on stemness and CSCs and the underlying mechanisms are still controversial