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Safe Profile and Optimal Dosing Oral supplementation with quercetin up to 1 g/day for 3 months has not resulted in significant adverse effects (111)

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Future trials must incorporate robust biomarkerssuch as NFB activation levels, tumor suppressor gene methylation status, or immune cell cytotoxicityto identify which patients are most likely to benefit

Data suggest that by 2040, the global incidence of CRC will increase by 3.2 million new cases, and mortality will rise by 1.6 million deaths, significantly contributing to the growing healthcare burden worldwide [3]