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FFAs or their metabolites such as ceramides, diacylglycerols, and acyl-CoA were also reviewed to activate PKC , leading to increased IRS1/2 phosphorylation in serine/threonine residues instead of tyrosine residue, thus causing an imbalance in the action of insulin in liver as well as in heart and skeletal muscles [4446]

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Plant, Cell Environ 38:266279 Sheehan D, Meade G, Foley VM, Dowd CA (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily