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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences

Even if small molecules manage to penetrate the BBB, they are often actively transported back out via efflux pumps ( 6.1 Focused ultra-sound FUS has been investigated as a method to transiently and non-invasively increase the permeability of the BBB, thereby enhancing the delivery of therapeutic agents to GB tissue

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