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Description
The activated PARPase utilizes NAD + as a substrate to transfer ADP-ribose units one by one to the target protein, forming poly ADP-ribose chains

Mechanistically, the overexpression of GPX4 protects cells from mitochondrial pathway-mediated apoptosis by blocking mitochondrial release of CYCS, inactivating CASP3, and inhibiting hydroperoxide production [15,100,102105] (Figure 5A)

doi: 10.1080/10408399409527669

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