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Interestingly, an inverse association between VitB12 and sleep was observed in the general population [15, 21, 22] and elder population (our T2DM patients), while this association was found to be reversed in the young population in two other studies [36, 37]

This suggests that CAQK interacts with a protein, not a glycosaminoglycan, in the CSPG complex

There is also a call for caution regarding proposals for mass fortification of products and foods with vitamin B12, as there may be more risks than benefits