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Interestingly, no significant differences were found in creatine kinase, IL-6, or TNF-alpha, suggesting that a larger dose of curcumin and a greater frequency of consumption on recovery days (post-exercise) may be needed to have more significant effects (251)

Numerous studies have found that pro-inflammatory factors such as IL-6, TNF-, and C-reactive protein are significantly elevated in the serum of patients with sarcopenia, while the anti-inflammatory factor IL-10 is notably decreased (Tuttle et al., 2020

Notably, tau protein lactylation at K677 initiates ferroautophagy and ferroptosis through the MAPK pathway, leading to microglial activation and neuroinflammation [82]