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Together, these two residues have been designated the Zn 2+ sensor because zinc is the most likely endogenous trigger [253]

Furthermore, both cysteine and glycine are incorporated into the tripeptide glutathione, and thus serine is critical for both cellular redox homeostasis and xenobiotic metabolism processes [64, 65]

[DOI] [PMC free article] [PubMed] [Google Scholar] 311.Dinan T.G

In conclusion, glutamine antimetabolites effectively inhibit tumor growth while improving the anti-tumor immune response through multiple mechanisms, revealing the close interaction between glutamine metabolism and immune response in the TME (Fig