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But some nutrients, like L-Carnitine, may be unfamiliar or completely foreign

Additionally, ketogenic diets can significantly extend the lifespan of mice with genetic lethal cardiomyopathy because they help maintain the integrity of cardiomyocytic mitochondrial structures and improve oxidative phosphorylation (Krebs et al., 2011)

Renal OCTN2 expression and activity increase when the carnitine concentration is reduced in the plasma and/or glomerular filtrate, whereas OCTN2 mRNA expression levels remain unchanged in the gut, liver, or skeletal muscle [254], highlighting the central role of the kidney in maintaining carnitine homeostasis

Hereditary causes include genetic defects in the metabolism of amino acids, cholesterol, and fatty acids, such as propionyl-CoA carboxylase deficiency (aka propionic acidemia) and medium chain acyl-CoA dehydrogenase deficiency (36)
