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While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

El-Sheikh AAK, Morsy MA, Mahmoud MM, Rifaai RA, Abdelrahman AM (2012) Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats [Article]

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