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Pharmacological treatment of diabetic peripheral neuropathy: an update

Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)

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