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gpx4 global knockout mice exhibit embryonic lethality, whereas gpx4 -related conditional knockout mice also display selective developmental defects, increased cell death, or disease susceptibility (Table 1)

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Glutathione - Synthesis SFRBM Education Program Dickinson et al.18 The Glutathione Cycle 2 lesson summary -glutamylcysteinylglycine -glutamyl-amino acid cys GGT cysteinylglycine amino acid gly extracellular dipeptidase GSH transporter Amino acid transporters intracellular -glu-amino acid amino acid 5-oxoproline ATP ADP -glutamylcysteinylglycine cysteine glycine -glutamylcysteine glutamate GSH synthase GCL ADP ATP ADP ATP Glutathione - Synthesis SFRBM Education Program Dickinson et al.19

The sites and topology of mitochondrial superoxide production