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This is driven by the likelihood of subchondral bone changes as a consequence of failed repair, particularly if the first attempt involved disruption of the tidemark for marrow recruitment

Late effects of chemotherapy and radiotherapy in osteosarcoma and Ewing sarcoma patients: the Italian Sarcoma Group experience Cancer 118 , 50505059 (2012)

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These studies report higher rates of erectile dysfunction in men diagnosed with male infertility compared to the general population
