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Inactive cereblon-based PROTACs After the discovery that thalidomide derivatives with N-alkylated glutarimide ring are unable to establish binding with cereblon E3 ligase, many research groups began to incorporate these derivatives in the construction of PROTACs with the aim of obtaining negative controls, and thus assessing whether PROTAC-induced degradation is or is not cereblon-dependent 52,189

The combined supernatants were concentrated under vacuum at a temperature of 37 C until dry

Introducing the concept of ferroptosis provides insights into a new pathogenic mechanism of iron-mediated diseases, encouraging researchers to delve deep into it

Morris, G., et al., The Glutathione System: A New Drug Target in Neuroimmune Disorders